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2 edition of intestinal absorption of the cadmium cation. found in the catalog.

intestinal absorption of the cadmium cation.

Jacqueline Louise Porter

intestinal absorption of the cadmium cation.

by Jacqueline Louise Porter

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  • 33 Currently reading

Published by University of Aston. Department of Chemistry in Birmingham .
Written in English


Edition Notes

Thesis (Ph.D.) - University of Aston in Birmingham 1982.

ID Numbers
Open LibraryOL13773916M

2 Based on a concept of two distinguishable steps, intestinal absorption of Cd is characterized by high accumulation within the intestinal mucosa and a low rate of diffusive transfer into the organism. 3 After uptake into the mammalian organism, Cd is sequestered into hepatic metallothionein (MT). When normal people ingest 90 mEq/day of K+ in their diet, they absorb about 90% of intake (81 mEq) and excrete an equivalent amount of K+ in the urine. Normal fecal K+ excretion averages about 9 mEq/day. The vast majority of intestinal K+ absorption occurs in the small intestine; the contribution of .

Intestinal calcium absorption involves two processes: a transcellular, metabolically driven transport and a paracellular, passive process. This article will describe these processes in detail and raise the question whether and how intestinal absorption of other minerals can be analyzed in comparable terms. Cadmium is a highly toxic metal that can damage a number of organs including the gastrointestinal tract. It has been shown that cadmium partially reduces L-threonine intestinal absorption probably.

  Recent work shows a possible role for cadmium in the development of osteoporosis (2). The intestinal absorption of cadmium increases when iron stores are depleted but the mechanism of cadmium uptake is not known (3,4). Both the size of the iron stores and the rate of erythropoiesis determine the intestinal iron absorption (5). Horiguchi H, Oguma E, Sasaki S, Miyamoto K, Ikeda Y, Machida M and Kayama F () Comprehensive study of the effects of age, iron deficiency, diabetes mellitus, and cadmium burden on dietary cadmium absorption in cadmium-exposed female Japanese farmers, Toxicology and Applied Pharmacology, /, , (), Online.


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Intestinal absorption of the cadmium cation by Jacqueline Louise Porter Download PDF EPUB FB2

The intestinal absorption of cadmium (Cd) increases when the body iron (Fe) stores are depleted. The depletion of Fe upregulates the expression of divalent metal transporter 1 (DMT1), which is located at the apical membrane of enterocytes lining the small intestine.

DMT1 has been shown to transport Fe and other divalent metal ions in by: Huebers HA, Huebers E, Csiba E, Rummel W, Finch CA. The cadmium effect on iron absorption. Am J Clin Nutr. May; 45 (5)– Wing AM. The effects of whole wheat, wheat bran and zinc in the diet on the absorption and accumulation of cadmium in rats.

Br J Nutr. Jan; 69 (1)–Cited by:   The intestinal absorption of cadmium (Cd) is influenced by body iron (Fe) status in laboratory animals and humans. In this study we investigated the role of the apical Fe transporter divalent metal transporter 1 (DMT1) and the basolateral Fe exporter metal transporter protein 1 (MTP1) in Cd by: Sasser LB, Jarboe GE.

Intestinal absorption and retention of cadmium in neonatal rat. Toxicol Appl Pharmacol. Aug; 41 (2)– LEVINE RR. The influence of the intraluminal intestinal milieu on absorption of an organic cation and an anionic agent.

J Pharmacol Exp Cited by:   The intestinal absorption of Intestinal absorption of the cadmium cation. book 2 ( nmol) and some cadmium complexes ( nmol) was investigated in rats. CdCl 2, or Cd complexed with cysteine or glutathione showed very similar absorption patterns, since Cd uptake by the intestinal epithelium was high (approximately to nmol after min) but the amount transferred (i.e.

absorbed) was relatively low (approximately 7 Cited by: Chronic exposure to cadmium (Cd) causes remarkable damage to the liver and gastrointestinal tract. Previous studies have revealed that chlorogenic acid (CGA) could improve the intestinal barrier integrity for weaned rats.

Hence, this study sought to investigate the protective effects of CGA from pur. Hamilton DL, Smith MW () Cadmium inhibits calcium absorption by rat intestine.

J Physiol P–55P PubMed Google Scholar Hamilton DL, Smith MW () Inhibition of intestinal calcium uptake by cadmium and the effect of a low calcium diet on cadmium retention. Sasser LB, Jarboe GE () Intestinal absorption and retention of cadmium in neonatal rat.

Toxicol Appl Pharmacol – PubMed CrossRef Google Scholar Sasser LB, Jarboe GE, Walter BK, Kelman BJ () Absorption of mercury from ligated segments of the rat gastrointestinal tract. to increase cadmium absorption compared to a single treat-ment both in vivo and in intestinal in vitro preparations of adult rats [ ].

However, even though MT involvement has been suggested, the cellular mechanism for how cadmium enhances its own absorption remains to be elucidated [ ]. Intestinal MT is induced by cadmium [ ], but there are. Purchase Nutrition, Digestion, Metabolism - 1st Edition. Print Book & E-Book.

ISBN  The site of cadmium and mercury retention in the intestine was determined in 6-day-old sucklings and 6-week-old weaned rats 6 days after oral administration of m Cd and Hg. The ileum was found to be the main site of intestinal retention of both cations in sucklings but not in weaned rats.

Also, cadmium in water is more easily absorbed than cadmium in food (5% in water versus % in food) (IRIS ). The presence of elevated zinc or chromium in the diet decreases cadmium uptake. Dermal. Absorption through the skin is not a significant route of cadmium entry; only about % of cadmium is absorbed by the skin (ATSDR ).

Results Effect of different cadmium concentrations on intestinal D-galactose accumulation In control conditions (in the absence of exoge- nous modifiers) the rates of absorption of D- galactose when present at concentrations of and 10 mM were and gmol D-galactose ml-t cell water in 20 minutes, respectively.

Intestinal absorption of cadmium (Cd) is considered to be mediated mainly by the ferrous iron transporter DMT1, or the calcium transporter CaT1. The roles of zinc transporters such as ZIP8 and ZIP14 remain unclear, and the roles of these four transporters in the intestinal uptake of Cd under physiological conditions have not been compared.

Reduction of the Intestinal Absorption of Glucose, Methionine and Sodium Butyrate by the Cation Trimethylhexadecylammonium J.

NISSIM 1 Nature volumepages – () Cite this. The intestinal absorption of the cadmium cation Author: Porter, Jacqueline L. ISNI: Awarding Body: University of Aston in Birmingham Current Institution: Aston University Date of Award: Availability of Full Text.

CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): The intestinal absorption of the nephrotoxic environmental pollutant cadmium increases markedly when iron stores are depleted.

This may be mediated by an up regulation of the recently identified mucosal transporter DMT1 (Nramp2 or DCT1) for divalent cations.

We tested whether the highly increased iron absorption. Lind Y, Wicklund GA () The involvement of metallothionein in the intestinal absorption of cadmium in mice. Toxicol Letts 91(3)– CrossRef Google Scholar Lind Y, Wicklund GA, Engman J, Jorhem L () Bioavailability of cadmium from crab hepatopancreas and mushroom in relation to inorganic cadmium: a 9-week feeding study in mice.

Intestinal Absorption of Metal Ions, Trace Elements, and Radionuclides focuses on the transport of metal ions across biological membranes. The selection first discusses fundamental considerations of ion transport across biological membranes, including passage of ions through the pores of gels or membranes; mobilities of organic and inorganic ions in water; and complexing of alkali metal ions.

Kello D, Dekanic D, Kostial K () Influence of sex and dietary calcium on intestinal cadmium absorption in rats. Arch Environ Health 30–33 PubMed Google Scholar Kerper LE, Ballatori N, Clarkson TW () Methylmercury transport across the blood-brain barrier by an amino acid carrier.

Effect of hemolytic and iron-deficiency anemia on intestinal absorption and tissue accumulation of cadmium. Min KS(1), Iwata N, Tetsutikawahara N, Onosaka S, Tanaka K. Author information: (1)Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Osaka, Japan. [email protected] vs. Absorption 39/10/96 PM Emission vs.

Absorption All modern Perkin-Elmer atomic absorption instruments are capable of measuring both atomic absorption and atomic emission. It is important for the operator to understand the .Thus particle size, which controls alveolar deposition, is a key determinant of cadmium absorption in the lung.

In humans, figures of % of absorption rate according to particle size are derived for Cd dusts. For Cd fumes, based on cigarette smoke studies, it can be calculated that the respiratory absorption of Cd fumes is between 25% and 50%.